Taiwan is facing issues such as water resource allocation and development of new public water due to affect by global climate change in recent years, resulting in extreme rainfall triggers frequent droughts and floods. The purpose of this course is to enable students to understand the connotation of healthy river basins, including the interrelationships between water resources, water pollution, and aquatic ecology. More importantly, the process of pollutants entering natural water bodies and their impact on water quality and ecology which have a further understanding of the fate and transport of pollutants in natural water bodies. And use the measured hydrological and water quality data as the basis for total maximum daily loads (TMDLs) and water quality prediction. Under the balance of water quantity and water quality, improve the domestic water resource utilization and water quality health and towards a sustainable and healthy water environment. This course corresponds to the United Nations Sustainable Development Goals of SDGs 2, 6, 12, and 13.