| 開課班級Class： | 授課教師Teacher： | 學分數Credits： |
| 碩生技一A | 蔡添順 | 2 |
| 課程大綱Course Description： |
| 蛇毒成分複雜且多樣化，不同蛇毒的毒性、藥理及臨床症狀各有特點，可分成神經毒、血循毒、壞死毒、心臟毒、腎臟毒、肌肉毒及其他類型。蛇毒學研究包含毒理學、基因體學、轉錄體學、蛋白質體學及抗血清蛋白質體學、以及醣類體學等層面。依據藥理特性，分離純化特殊蛇毒蛋白，再結合分子生物學及結構化學的方法，可應用於製藥、檢驗和抗蛇毒血清的製造。蛇毒成份目前已被應用於治療糖尿病、高血壓、慢性疼痛及腦中風等病症，以及抗凝血與消炎作用。本課程主要介紹蛇毒多樣性以及蛇毒研究方法、成果、發展及蛇毒科技應用，修課學生也會進行文獻研讀與口頭報告。 |
| English Outline： |
| Snake venom is complex and diverse in composition and varied in the toxicity, pharmacology, and clinical symptoms, which can be divided into neurotoxin, hemostasis toxin, necrotoxin, cardiotoxin, nephrotoxin, myotoxin, and other types. Snake venom researches include toxicology, genomics, transcriptomics, proteomics, antiveomics, and glycomics. According to the pharmacological properties, the separation and purification of specific venom proteins, combined with the approaches of molecular biology and structural chemistry, can be used in the pharmaceutical, examination, and antivenom manufacture. Snake venom compositions have been used in treating diabetes, hypertension, chronic pain, and stroke, as well as displaying anticoagulant and anti-inflammatory effects. This course mainly aims to present the diversity of snake venoms as well as the method, achievement, development, and application of snake venom technology. Students in the course will also read literatures and make oral presentations. |
| 本科目教學目標Course Objectives： |
| 1. [知識]瞭解蛇毒成分、多樣性及研究方法。 2. [技能]與組員合作進行文獻研讀與口頭報告。 3. [能力]能理解蛇毒科技發展現況及應用。 4. [態度]體認蛇毒科技的重要性。 |
| 教學型態Teaching Models： | 成績考核方式Grading： |
| 課堂教學+小組討論 | 平時成績General Performance：40% 期中考Midterm Exam：30% 期末考Final exam：30% 其它 Other：1. 若無法出席，應按規定辦理正式請假手續；未辦理請假而缺席者為曠課。 2. 缺曠課時小考不予補考，以零分計算。 |
| 參考書目Textbooks/References： |
| Mackessy, SP. (editor) 2021. Handbook of Venoms and Toxins of Reptiles (2nd ed.). Boca Raton: CRC Press/Taylor & Francis, FL, USA. 662 pages. [ISBN-10: 0367149745; ISBN-13: 978-0367149741] Fry, BG. (editor) 2015. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Oxford University Press, NY, USA. 576 pages. [ISBN-10: 9780199309399; ISBN-13: 978-0199309399] Mackessy, SP. (editor) 2010. Handbook of Venoms and Toxins of Reptiles. Boca Raton: CRC Press/Taylor & Francis, FL, USA. 528 pages. |
| SDGs指標： |
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| 課程匯入時間Import Time：2024-01-23 08:13:52 |
| 最後更新時間Last Modified：2024-01-23 09:08:47，更新人modified by： |