The aim of this course unit is to acquaint the student with the concept and applications of synthetic materials as prostheses for natural tissue replacement, and the mechanical behaviour of components of human body. The content includes Describe the requirements for synthetic implant materials in biomedical applications、Assess various materials in relation to their suitability for implant materials、Describe the function and degradation of synthetic replacement materials in vitro and in vivo、Discuss the concept of bioactivity by biocompatibility testing、Understand generation of forces within the body and the behaviour of the structures in resisting these forces. Illustrate fundamental tissue engineering and biomimetic materials.