The farming of aquatic animals including fish and shellfish remains a repaid growth industry to meet the global demand of sea food. The use of herbal medicine to control disease becomes an alternative to develop an effective and sustainable aquaculture. The course contents cover major traditional herbal medicines used on aquatic animals mainly fish and shrimp. The herbal preparation, delivery, immune modulation effects and enhancement of disease resistance are discussed. Analysis of functional ingredients and mechanisms also are included. In addition, current literature reviews on the use of herbal medicines on fish and shrimp are introduced.