Computer Numerical Control (CNC) machine is the main force of today's machinery industry, as the role of workpiece logistics and machine series in series, the industrial robot arm is the best assistant for smart manufacturing. The purpose of this course is to introduce the industrial robot in Computer-Integrated Manufacturing (CIM) system, the topics cover programming practice and operation for computer numerical controlled machine, robotic end-effector, sensors, actuators, signals processing, programmable logic controller, etc., to control the mechanism to reach the function.