This course will develop the deeper understanding of both concepts and skills in fermentation engineering. These include skills in aseptic manipulation, microbial isolation and screening, microbial growth and sampling and analysis, and technologies in liquid and solid state of fermentation, In addition, this course will allow students hand-on experience in using steam-in-place (SIP) bioreactor for culture solution preparation, and harvesting the concentrated product by spray drying technology. Expects in this field will be invited to give lectures and demonstrations in lab. In such, students are given the opportunity to understand practical operation management in industry. With the combination of knowledge gained in class, students in this course will be mastering their skills well.