The most significant scientific paradigm shift and technological innovation in the 21st century is the invention and widespread application of artificial intelligence. Especially in accelerating the provision of solutions to sustainable development problems, digitalization and ESG practice have become equally famous in academic research and practical implementation as generating opportunities and challenges in dual-axis transformation. Not only has traditional corporate social responsibility (CSR) been gradually replaced by ESG (environment, society and governance), various central-government level public policy formulations in the public sector and local government urban governance have also included seventeen UN SDGs through the Voluntary Review Report on Sustainable Development (VLR) for strategic and cross-sectoral integration. In addition, the public and private sectors are increasing the application of artificial intelligence technology in platform economy and platform digital governance year by year, creating a new term and trend called digitainability. In the context of the above academic and practical development, this course hopes to lead students to start by understanding the historical development and theoretical background of the dual-axis transformation of digitalization and ESG, and then sequentially explore the diverse aspects of artificial intelligence in the application of United Nations' seventeen sustainable development goals. Furthermore, a critical reflection on the multi-faceted challenges that may arise when seeking solutions to every sustainable development problem from artificial intelligence is carried out, training students to gradually adopt digital-oriented thinking and make good use of technological innovation to solve difficult and highly interdependent socio-economic problems.