Aquaculture is the most important commercial behavior in Taiwan, such as fish, shrimps and shellfish culture. During the culture process, aquatic organisms are susceptible to foreign pathogens, leading to the lethality of organisms. To the previous research, through immunomodulatory substances, the fish diseases can be effectively under control and the risk of breeding can be reduced. In academic research, a variety of substances with immunomodulatory functions have been published, therefore, this course is mainly designed to understand the immunomodulatory substances contained in natural products, as well as their functions and purification methods. The main operations in the internship course is including of the aquatic animal cell culture technology, water extraction of natural products and macromolecular polysaccharide extraction methods, and field to learn material safety and functional evaluation in the cell level.