Management information system is the strategic core competence of e-business. The purpose of this course is to introduce the role of MIS and its applications. Principle of MIS and system design methodologies are also discussed. Course contents include understanding the meaning and characteristics of information and knowledge, the needs and applications of the MIS, the Organizations, planning and controlling of the MIS. And, related topics with managerial overview of MIS are introduced by the interactive theory of IT and organization. Finally, in order to achieving the objectives of this course, the impacts of network economy and new IT of e-business are also discussed through empirical study cases.